Archive for the ‘Healthy bones Osteoporosis Rheumatic’ Category

posted by admin on May 17

Methotrexate (Rheumatrex) has become increasingly popular for rheumatoid arthritis. It is an immune suppressant first developed for cancer chemotherapy. It can also be used to treat rheumatoid arthritis, juvenile rheumatoid arthritis, and lupus. Methotrexate has recently begun to be classed as a potential disease-modifying drug for rheumatoid arthritis. Methotrexate often leads to improvement in symptoms within a month.However, it can cause a host of side effects, including loss of appetite, nausea and vomiting, intestinal ulceration and, in some cases, bone marrow suppression and severe liver damage. As with sulfasalazine, patients taking methotrexate must be monitored for white blood cell count during therapy. Other side effects include headache, fatigue, malaise, and inflammation of the mouth (stomatitis).Lung inflammation, one of the most unpredictable and potentially serious side effects of treatment with methotrexate, can occur at relatively low doses. Symptoms include shortness of breath, cough, fatigue, and fever. In addition to lung disease, methotrexate can cause an increased incidence of bronchitis and pneumonia.There is also concern that methotrexate might increase the risk of blood cancers such as leukemia and lymphoma. Although the evidence is contradictory, one study concluded that the spontaneous remission of lymphomas in rheumatoid arthritis patients after methotrexate was stopped was reason enough to further investigate the drugs role in development of these cancers.*26/306/5*

posted by admin on Mar 13

The basic function of cartilage is to absorb shock and protect the bones. There are two types of cartilage in the knee joint: articular cartilage and the menisci.
The articular cartilage, also known as hyaline cartilage, is a white elastic material that lines the three bones that form the knee joint: the patella, femur and tibia. It is anywhere from 1/8 to 1/2 inch in thickness. Articular cartilage allows the knee (and other joints) to move in a fluid motion. Articular cartilage is composed primarily of water, collagen, and substances called proteoglycans, which are made up of large proteins and sugars. The wearing away of the articular cartilage, either through a traumatic injury or overuse, can result in arthritis. Softening or wearing away of the articular cartilage is called chondromalacia. Severe arthritis becomes evident when the hyaline cartilage is completely worn exposing raw bone (the subchondral bone).
Each knee has two menisci: the medial mensicus and lateral meniscus. (Medial refers to a part that is closest to the other leg, lateral refers to a part that is further away from the other leg.) The menisci are made of fibrous cartilage, a thick rubbery-type substance. Located on top of the tibial plateau, both menisci are basically shock absorbers, helping the knee withstand the enormous shear (side) forces that are placed on it daily. Meniscal injuries are fairly common, especially among athletes and are often a result of excessive force. Wear and tear due to age can also cause damage to the menisci.